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[血小板活化因子(PAF)对特应性哮喘患者体内粒细胞迁移的影响]

[Effect of platelet activating factor (PAF) on granulocyte migration in vivo in patients with atopic asthma].

作者信息

Matusiewicz R, Urbankowska B, Kowalczyk M

机构信息

Oddział Chorób Wewnetrznych Szpitala Grochowskiego, Warszawie.

出版信息

Pneumonol Alergol Pol. 1991;59(11-12):31-4.

PMID:1843897
Abstract

The study was carried out in 40 patients with atopic asthma, age 16-31 years (mean 26 years) and 30 healthy volunteers, age 19-25 years (mean 20 years). In vivo granulocyte migration tests were carried out simultaneously using two methods: Southam's and the authors' original (Matusiewicz, Brzezińska). The above mentioned tests were carried out twice: the first time in December/January, the second time February/March after subcutaneous administration of PAF. The authors have demonstrated that in patients with atopic asthma a defect in migration of tissue granulocytes is present. They have also shown that PAF does not effect significantly granulocyte migration in atopic patients.

摘要

该研究对40例年龄在16至31岁(平均26岁)的特应性哮喘患者和30例年龄在19至25岁(平均20岁)的健康志愿者进行。采用两种方法同时进行体内粒细胞迁移试验:索瑟姆法和作者原创的方法(马图谢维茨、布热津斯卡法)。上述试验进行了两次:第一次在12月/1月,第二次在皮下注射血小板活化因子(PAF)后的2月/3月。作者已证明,特应性哮喘患者存在组织粒细胞迁移缺陷。他们还表明,PAF对特应性患者的粒细胞迁移没有显著影响。

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