伊朗浸润性导管癌乳腺癌患者染色体畸变的比较基因组杂交（CGH）分析。
Comparative genomic hybridization (CGH) analysis of chromosomal aberrations in Iranian patients with invasive ductal carcinoma breast cancer.
作者信息
Ghaffari Saeed R, Sabokbar Tayebeh, Pour Peyman Noshiravan, Dastan Jila, Mehrkhani Farhad, Shoraka Solmaz, Mohagheghi Mohammad Ali, Tirgari Farrokh, Mosavi-Jarrahi Alireza
机构信息
Dept of Genomics, Cancer Institute Research Center, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Asian Pac J Cancer Prev. 2008 Jan-Mar;9(1):66-70.
INTRODUCTION
Breast cancer is one of the most common cancers in women; however, due to the complexity of chromosomal changes, limited data are available regarding chromosomal constitution.
MATERIALS AND METHODS
In this study, Comparative Genomic Hybridization (CGH) was used on 16 Iranian patients diagnosed with invasive ductal breast carcinomas.
RESULTS
12 samples had abnormal CGH results (75%), including 21 types of chromosomal imbalance. The most prevalent were chromosomal gain of +1q, +17q, +8q and chromosomal loss of -13q. All three cases with DNA loss at chromosome 13q (-13q) had lymph node metastasis.
CONCLUSIONS
CGH is able to detect chromosomal abnormalities which are difficult to identify by conventional cytogenetic techniques. More studies on a larger sample size may help to confirm or rule out any possible correlation between 13q monosomy and lymph node metastasis, which could result in establishing new strategies for prevention and early detection of invasive breast tumors.
引言
乳腺癌是女性最常见的癌症之一；然而，由于染色体变化的复杂性，关于染色体构成的数据有限。
材料与方法
在本研究中，对16例诊断为浸润性导管癌的伊朗患者进行了比较基因组杂交（CGH）检测。
结果
12个样本的CGH结果异常（75%），包括21种染色体失衡类型。最常见的是+1q、+17q、+8q染色体增加和-13q染色体缺失。所有3例13号染色体q臂缺失（-13q）的病例均有淋巴结转移。
结论
CGH能够检测出传统细胞遗传学技术难以识别的染色体异常。对更大样本量进行更多研究可能有助于证实或排除13q单体性与淋巴结转移之间的任何可能关联，这可能会促成制定浸润性乳腺肿瘤预防和早期检测的新策略。
Zotero 插件