凋亡抑制蛋白：名字里有什么含义？
IAPs: what's in a name?
作者信息
Srinivasula Srinivasa M, Ashwell Jonathan D
机构信息
Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Mol Cell. 2008 Apr 25;30(2):123-35. doi: 10.1016/j.molcel.2008.03.008.
Abstract
Originally described in insect viruses, cellular proteins with Baculoviral IAP repeat (BIR) motifs have been thought to function primarily as inhibitors of apoptosis. The subsequent finding that a subset of IAPs that contain a RING domain have ubiquitin protein ligase (E3) activity implied the presence of other functions. It is now known that IAPs are involved in mitotic chromosome segregation, cellular morphogenesis, copper homeostasis, and intracellular signaling. Here, we review the current understanding of the roles of IAPs in apoptotic and nonapoptotic processes and explore the notion that the latter represents the primary physiologic activities of IAPs.
摘要
最初在昆虫病毒中被描述的、具有杆状病毒IAP重复序列（BIR）基序的细胞蛋白，一直被认为主要作为细胞凋亡的抑制剂发挥作用。随后发现，一部分含有RING结构域的IAP具有泛素蛋白连接酶（E3）活性，这暗示了它们还存在其他功能。现在已知IAP参与有丝分裂染色体分离、细胞形态发生、铜稳态和细胞内信号传导。在这里，我们综述了目前对IAP在凋亡和非凋亡过程中作用的理解，并探讨了后者代表IAP主要生理活性的观点。
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Design and characterization of bivalent Smac-based peptides as antagonists of XIAP and development and validation of a fluorescence polarization assay for XIAP containing both BIR2 and BIR3 domains.基于Smac的双价肽作为XIAP拮抗剂的设计与表征以及针对包含BIR2和BIR3结构域的XIAP的荧光偏振测定法的开发与验证。
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