Fan Hui, Liu Jiyuan, Hu Xiangyan, Cai Jiye, Su Bo, Jiang Jinhuan
Institute of Pharmacy and Pharmacology, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Department of Chemistry, Jinan University, Guangzhou, 510632, China.
Apoptosis. 2025 Mar 27. doi: 10.1007/s10495-025-02101-4.
X-linked inhibitor of apoptosis protein (XIAP) is the most potent endogenous member of the inhibitor of apoptosis protein family. XIAP exerts its anti-apoptotic effects by inhibiting both the death receptor pathway and mitochondrial pathway of apoptosis through various mechanisms such as directly binding to caspases, activating the nuclear factor kappa B (NF-κB) pathway, and other signaling pathways. These processes are closely related to tumor development and progression, making XIAP a therapeutic target for various types of cancer. This article will first review the structural characteristics and biological functions of XIAP, followed by its effects on tumors and an overview of XIAP-targeted inhibitors.
X连锁凋亡抑制蛋白（XIAP）是凋亡抑制蛋白家族中最具活性的内源性成员。XIAP通过多种机制抑制凋亡的死亡受体途径和线粒体途径，从而发挥其抗凋亡作用，这些机制包括直接与半胱天冬酶结合、激活核因子κB（NF-κB）途径以及其他信号通路。这些过程与肿瘤的发生和发展密切相关，使得XIAP成为各类癌症的治疗靶点。本文将首先综述XIAP的结构特征和生物学功能，随后阐述其对肿瘤的影响以及XIAP靶向抑制剂的概述。
