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本文引用的文献

1
Development of a non-human primate sperm aneuploidy assay tested in the rhesus macaque (Macaca mulatta).在恒河猴（猕猴）中测试的非人灵长类动物精子非整倍体检测方法的开发。
Mol Hum Reprod. 2007 Jul;13(7):455-60. doi: 10.1093/molehr/gam024. Epub 2007 May 3.
2
High incidence of complex chromosome abnormality in cleavage embryos from patients with repeated implantation failure.反复种植失败患者卵裂期胚胎复杂染色体异常的高发生率。
Fertil Steril. 2007 May;87(5):1053-8. doi: 10.1016/j.fertnstert.2006.11.043. Epub 2007 Apr 6.
3
Trisomy 17 in a baboon (Papio hamadryas) with polydactyly, patent foramen ovale and pyelectasis.一只患有多指畸形、卵圆孔未闭和肾盂积水的阿拉伯狒狒（Papio hamadryas）出现17三体。
Am J Primatol. 2007 Oct;69(10):1105-18. doi: 10.1002/ajp.20424.
4
Effects of rhFSH dose on ovarian follicular response, oocyte recovery and embryo development in rhesus monkeys.重组人促卵泡激素剂量对恒河猴卵巢卵泡反应、卵母细胞回收及胚胎发育的影响
Theriogenology. 2007 Apr 1;67(6):1194-201. doi: 10.1016/j.theriogenology.2006.10.021. Epub 2007 Feb 26.
5
A molecular model for sporadic human aneuploidy.散发性人类非整倍体的分子模型。
Trends Genet. 2006 Apr;22(4):218-24. doi: 10.1016/j.tig.2006.02.007. Epub 2006 Feb 23.
6
Mitochondrial DNA deletions in rhesus macaque oocytes and embryos.恒河猴卵母细胞和胚胎中的线粒体DNA缺失
Mol Hum Reprod. 2005 Nov;11(11):785-9. doi: 10.1093/molehr/gah227. Epub 2005 Dec 22.
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Ovarian aging and menopause: current theories, hypotheses, and research models.卵巢衰老与绝经：当前的理论、假说及研究模型。
Exp Biol Med (Maywood). 2005 Dec;230(11):818-28. doi: 10.1177/153537020523001106.
8
A male baboon (Papio hamadryas) with a mosaic 43,XXY/42,XY karyotype.
Am J Med Genet A. 2006 Jan 1;140(1):94-7. doi: 10.1002/ajmg.a.31014.
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Trisomy of chromosome 18 in the baboon (Papio hamadryas anubis).狒狒（阿拉伯狒狒）18号染色体三体。
Cytogenet Genome Res. 2006;112(1-2):76-81. doi: 10.1159/000087516.
10
Preimplantation genetic diagnosis and chromosome analysis of blastomeres using comparative genomic hybridization.使用比较基因组杂交技术对卵裂球进行植入前基因诊断和染色体分析。
Hum Reprod Update. 2005 Jan-Feb;11(1):33-41. doi: 10.1093/humupd/dmh050. Epub 2004 Nov 29.

恒河猴植入前胚胎中的染色体不稳定性

Chromosomal instability in rhesus macaque preimplantation embryos.

作者信息

Dupont Cathérine, Froenicke Lutz, Lyons Leslie A, Bavister Barry D, Brenner Carol A

机构信息

Departments of Obstetrics & Gynecology and Physiology, CS Mott Center for Human Growth and Development, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA.

出版信息

Fertil Steril. 2009 Apr;91(4):1230-7. doi: 10.1016/j.fertnstert.2008.01.075. Epub 2008 Apr 28.

DOI:10.1016/j.fertnstert.2008.01.075
PMID:18440514
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3082460/
Abstract

OBJECTIVE

To establish a relevant animal model to systematically investigate chromosomal instability in human oocytes and preimplantation embryos.

DESIGN

Prospective rhesus monkey IVF study.

SETTING

Academic laboratory, Oregon National Primate Research Center and Caribbean Primate Research Center.

ANIMAL(S): Young rhesus macaque females.

INTERVENTION(S): In vitro produced entire rhesus macaque preimplantation embryos were cytogenetically assessed using a five-color fluorescent in situ hybridization assay developed for rhesus macaque chromosomes homologous to human chromosomes 13, 16, 18, X, and Y, using human bacterial artificial chromosome probes.

MAIN OUTCOME MEASURE(S): Chromosomal abnormality rates in preimplantation embryos from young rhesus macaque females were established.

RESULT(S): Fifty preimplantation embryos, displaying good morphology and normal development, were analyzed from 11 young rhesus macaque females. Overall, 27 embryos (54%) were normal, 11 embryos (22%) mosaic, 3 embryos (6%) chaotic, 2 embryos (4%) aneuploid, 3 embryos (6%) haploid, and 4 embryos (8%) triploid.

CONCLUSION(S): These data indicate that in vitro produced rhesus macaque and human preimplantation embryos exhibit similar numerical chromosomal aberrations. Rhesus macaques appear to be a suitable animal model for investigating the origin of chromosomal instability observed in human preimplantation embryos.

摘要

目的

建立一个相关动物模型，以系统研究人类卵母细胞和植入前胚胎中的染色体不稳定性。

设计

恒河猴体外受精前瞻性研究。

地点

学术实验室，俄勒冈国家灵长类动物研究中心和加勒比灵长类动物研究中心。

动物

年轻的恒河猴雌性。

干预措施

使用为与人类13、16、18、X和Y染色体同源的恒河猴染色体开发的五色荧光原位杂交分析法，对体外产生的整个恒河猴植入前胚胎进行细胞遗传学评估，使用人类细菌人工染色体探针。

主要观察指标

确定年轻恒河猴雌性植入前胚胎的染色体异常率。

结果

对11只年轻恒河猴雌性的50个形态良好、发育正常的植入前胚胎进行了分析。总体而言，27个胚胎（54%）正常，11个胚胎（22%）为嵌合体，3个胚胎（6%）混乱，2个胚胎（4%）非整倍体，3个胚胎（6%）单倍体，4个胚胎（8%）三倍体。

结论

这些数据表明，体外产生的恒河猴和人类植入前胚胎表现出相似的染色体数目畸变。恒河猴似乎是研究人类植入前胚胎中观察到的染色体不稳定性起源的合适动物模型。