Varlet P, Pasquier B, Miquel C, Beuvon F, Daumas-Duport C
Service de pathologie, centre hospitalier Sainte-Anne, 1, rue Cabanis, 75674 Paris cedex 14, France.
Neurochirurgie. 2008 May;54(3):159-65. doi: 10.1016/j.neuchi.2008.02.038. Epub 2008 Apr 28.
Nontumoral epileptogenic lesions account for the major pathological group of surgical specimens obtained from patients with temporal or extratemporal drug-resistant epilepsy. Hippocampal sclerosis remains the predominant etiology, but cerebral cortical dysplasias actually make up the second major cause of nontumoral epilepsy and are increasingly recognized. The percentage of vascular lesions or glial/glio-mesodermal scars remains stable, but the minor or nonspecific lesion group is decreasing because of imaging investigation technique improvement.
非肿瘤性致痫性病变是颞叶或颞叶外药物难治性癫痫患者手术标本的主要病理类型。海马硬化仍然是主要病因,但大脑皮质发育异常实际上是非肿瘤性癫痫的第二大病因,且日益受到认可。血管病变或神经胶质/神经胶质-中胚层瘢痕的比例保持稳定,但由于影像学检查技术的改进,轻微或非特异性病变组的比例正在下降。