厚朴酚是一种天然的治疗候选药物，可诱导卵巢肿瘤细胞凋亡并抑制其血管生成。
Honokiol, a natural therapeutic candidate, induces apoptosis and inhibits angiogenesis of ovarian tumor cells.
作者信息
Li Zhengyu, Liu Yi, Zhao Xia, Pan Xiaoling, Yin Rutie, Huang Canhua, Chen Lijuan, Wei Yuquan
机构信息
Department of Obstetrics and Gynecology, West China Second Hospital of Sichuan University, Renmin South Road, Chengdu 610041, People's Republic of China.
出版信息
Eur J Obstet Gynecol Reprod Biol. 2008 Sep;140(1):95-102. doi: 10.1016/j.ejogrb.2008.02.023. Epub 2008 Apr 28.
OBJECTIVES
To observe the anti-tumor activities of honokiol on human ovarian tumor in vitro and in vivo.
STUDY DESIGN
Cells were treated with honokiol, and the effects on proliferation and apoptosis were examined by MTT, DNA ladder, Hoechst staining, and flow cytometry assays. Expression of Bcl-2 members and caspase-3 were assessed. Measurements of tumor volume and microvessel densities (MVDs) were performed.
RESULTS
Honokiol significantly inhibited proliferation and induced apoptosis, with alteration of Bcl-2 members and caspase-3. Administration of honokiol to tumor-bearing animals decreased MVD and resulted in inhibition of tumor growth.
CONCLUSIONS
Honokiol could induce apoptosis and inhibit angiogenesis in vitro and in vivo, suggesting a novel and attractive therapeutic candidate for ovarian tumor treatment.
目的
观察厚朴酚对人卵巢肿瘤的体内外抗肿瘤活性。
研究设计
用厚朴酚处理细胞，通过MTT法、DNA梯状条带分析、Hoechst染色和流式细胞术检测其对细胞增殖和凋亡的影响。评估Bcl-2家族成员和半胱天冬酶-3的表达。测量肿瘤体积和微血管密度（MVD）。
结果
厚朴酚显著抑制细胞增殖并诱导凋亡，同时改变了Bcl-2家族成员和半胱天冬酶-3的表达。给荷瘤动物施用厚朴酚可降低MVD并抑制肿瘤生长。
结论
厚朴酚在体内外均可诱导凋亡并抑制血管生成，提示其可能是一种新型且有吸引力的卵巢肿瘤治疗候选药物。
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