Gerald J. Friedman Diabetes Institute at Lenox Hill Hospital, Northwell Health, New York, NY, 10022, USA.
Division of Endocrinology and Metabolism, Department of Medicine, Friedman Diabetes Institute at Lenox Hill Hospital, Northwell Health, 110 E 59th Street, Suite 8B, Room 837, New York, NY, 10022, USA.
Mol Med. 2018 Jun 5;24(1):29. doi: 10.1186/s10020-018-0032-7.
Breast cancer is the most common cancer among women as metastasis is currently the main cause of mortality. Breast cancer cells undergoing metastasis acquire resistance to death signals and increase of cellular motility and invasiveness.Plants are rich in polyphenolic compounds, many of them with known medicinal effects. Various phyto-polyphenols have also been demonstrated to suppress cancer growth. Their mechanism of action is usually pleiotropic as they target multiple signaling pathways regulating key cellular processes such as proliferation, apoptosis and differentiation. Importantly, some phyto- polyphenols show low level of toxicity to untransformed cells, but selective suppressing effects on cancer cells proliferation and differentiation.In this review, we summarize the current information about the mechanism of action of some phyto-polyphenols that have demonstrated anti-carcinogenic activities in vitro and in vivo. Gained knowledge of how these natural polyphenolic compounds work can give us a clue for the development of novel anti-metastatic agents.
乳腺癌是女性中最常见的癌症，因为转移是目前导致死亡的主要原因。发生转移的乳腺癌细胞对死亡信号和细胞迁移性及侵袭性的增加具有抗性。植物富含多酚类化合物，其中许多具有已知的药用功效。已经证明，各种植物多酚也能抑制癌症的生长。它们的作用机制通常是多效性的，因为它们针对调节细胞增殖、凋亡和分化等关键细胞过程的多个信号通路。重要的是，一些植物多酚对未转化细胞的毒性水平较低，但对癌细胞的增殖和分化具有选择性抑制作用。在这篇综述中，我们总结了一些植物多酚的作用机制的最新信息，这些多酚在体内和体外都表现出了抗癌活性。了解这些天然多酚类化合物的作用机制可以为开发新型抗转移药物提供线索。
