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基因观察:用于关联研究的疾病基因挖掘浏览器。

GenoWatch: a disease gene mining browser for association study.

作者信息

Chen Yan-Hau, Liu Chuan-Kun, Chang Shu-Chuan, Lin Yi-Jung, Tsai Ming-Fang, Chen Yuan-Tsong, Yao Adam

机构信息

National Genotyping Center (NGC) and Institute of Biomedical Sciences (IBMS), Academia Sinica, Taipei, Taiwan 11529, R.O.C.

出版信息

Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W336-40. doi: 10.1093/nar/gkn214. Epub 2008 Apr 25.

Abstract

A human gene association study often involves several genomic markers such as single nucleotide polymorphisms (SNPs) or short tandem repeat polymorphisms, and many statistically significant markers may be identified during the study. GenoWatch can efficiently extract up-to-date information about multiple markers and their associated genes in batch mode from many relevant biological databases in real-time. The comprehensive gene information retrieved includes gene ontology, function, pathway, disease, related articles in PubMed and so on. Subsequent SNP functional impact analysis and primer design of a target gene for re-sequencing can also be done in a few clicks. The presentation of results has been carefully designed to be as intuitive as possible to all users. The GenoWatch is available at the website http://genepipe.ngc.sinica.edu.tw/genowatch.

摘要

一项人类基因关联研究通常涉及多个基因组标记,如单核苷酸多态性(SNP)或短串联重复多态性,并且在研究过程中可能会识别出许多具有统计学意义的标记。GenoWatch可以实时从许多相关生物数据库中以批处理模式高效地提取有关多个标记及其相关基因的最新信息。检索到的全面基因信息包括基因本体、功能、途径、疾病、PubMed中的相关文章等。只需点击几下,还可以进行后续的SNP功能影响分析和用于重测序的目标基因引物设计。结果展示经过精心设计,对所有用户来说都尽可能直观。可通过网站http://genepipe.ngc.sinica.edu.tw/genowatch访问GenoWatch。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18cb/2447740/97b8d842bfba/gkn214f1.jpg

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