Oishi Taku, Fujieda Mikiya, Shiraishi Taisuke, Ono Miki, Inoue Kazuo, Takahashi Akiyoshi, Ogura Hideo, Wakiguchi Hiroshi
Department of Pediatrics, Kochi National Hospital, Kochi, Japan.
Circ J. 2008 May;72(5):850-2. doi: 10.1253/circj.72.850.
Tumor necrosis factor-alpha (TNF-alpha) is considered to be 1 of the factors that induce vasculitis, including coronary artery aneurysm (CA), in Kawasaki disease (KD), because the blood concentration of TNF-alpha is higher in patients with CA compared with those without. Therefore, an anti-TNF-alphaagent (infliximab) was administered to a 1-month-old girl with refractory KD complicated by CA and subsequently, the CA improved and KD was controlled without complications 20 months after the onset.
肿瘤坏死因子-α（TNF-α）被认为是诱发包括川崎病（KD）冠状动脉瘤（CA）在内的血管炎的因素之一，因为与未患冠状动脉瘤的患者相比，患冠状动脉瘤的川崎病患者血液中TNF-α的浓度更高。因此，一名1个月大患有难治性川崎病并伴有冠状动脉瘤的女童接受了抗TNF-α药物（英夫利昔单抗）治疗，随后冠状动脉瘤病情改善，川崎病在发病20个月后得到控制，且未出现并发症。
