[A comparative study of leptin content in diabetics and obese subjects].

AIM

To compare leptin content in morphologically heterogenic group of patients with type 2 diabetes mellitus and obese patients without family history of diabetes.

MATERIAL AND METHODS

Leptin concentration was estimated with enzyme immunoassay (Leptin kit Sandwish ELISA, DRG diagnostics GmdH) in 21 patients with type 2 diabetes mellitus (2DM) and 12 obese patients without family history of diabetes. Distribution of patients with a documented diagnosis type 2 diabetes mellitus was conducted with application of instruments for antropometric examination (G.P. Gneupel, Switzerland). Statistic processing was made with the program Statistica 6 using Student's t-criterion.

RESULTS

Patients with diabetes mellitus and phenotypical marker of 2DM had the lowest level of leptin (mean leptin level 1.99 ng/ml in males, 11.01 ng/ml in females versus 2DM patients without the marker (mean leptin level 9.16 n/mg in males, 23.56 n/mg in females) and control group (13.86 ng/ ml in males, 22.55 ng/ml in females).

CONCLUSION

There is a correlation between leptin concentration and anthropological features of the patients.