Karoli N A, Rebrov A P
Klin Med (Mosk). 2008;86(3):18-21.
The purpose of research was to study the role of comorbidity in mortality of patients with chronic obstructive pulmonary disease (COPD). 78 patients with COPD were being dynamically observed during 4 years. 18 patients (23.1%) died in that period. Upon the average, it was detected 3.35 +/- 0.24 chronic diseases in the patients with COPD and 5.11 +/- 0.62 in died patients (p < 0.01). In died patients myocardium infarction was registered 3.3 times more frequently (p = 0.05), signs of blood circulation insufficiency--also 3.3 times more frequently and heart rhythm disturbances - 2 times more frequently. Average index of comorbidity was 3.00 +/- 0.19 in patients with COPD. Significant difference between indexes of comorbidity in died and survived patients (p < 0.001) was established. Therefore, COPD comorbidity is a marker of survival rate, and doctors have to consider it developing the plan of COPD therapy. Index of comorbidity can be used in clinical practice as a simple way of COPD death risk determination. When this index is more than 3, a patient has a high risk of death.
本研究的目的是探讨合并症在慢性阻塞性肺疾病(COPD)患者死亡率中的作用。对78例COPD患者进行了为期4年的动态观察。在此期间,18例患者(23.1%)死亡。COPD患者平均被检测出患有3.35±0.24种慢性病,死亡患者为5.11±0.62种(p<0.01)。死亡患者中心肌梗死的发生率高出3.3倍(p=0.05),血液循环不足的体征高出3.3倍,心律失常高出2倍。COPD患者的合并症平均指数为3.00±0.19。已确定死亡患者和存活患者的合并症指数存在显著差异(p<0.001)。因此,COPD合并症是生存率的一个指标,医生在制定COPD治疗方案时必须予以考虑。合并症指数可在临床实践中作为一种简单的确定COPD死亡风险的方法。当该指数大于3时,患者有较高的死亡风险。