[高强度聚焦超声治疗细粒棘球蚴包虫囊肿的病理变化]
[Pathological change in hydatid cysts of Echinococcus granulosus treated with high intensity focused ultrasound].
作者信息
Wang Jun-An, Zou Xiao-Yi, Ye Bin, Zhang Cheng-Wu, Zhao Fa-Sheng
机构信息
Department of Pathobiology, Chongqing Medical University, Chongqing 400016, China.
出版信息
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2007 Dec;25(6):462-5.
OBJECTIVE
To investigate the pathological change in Echinococcus granulosus hydatid cysts treated with high intensity focus ultrasound (HIFU).
METHODS
Thirty cysts with thinner wall and proper elasticity, taken from livers of infected sheep, were randomly divided into three groups. By cyclical multilayer radiation around the cyst wall, two experiment groups were treated with HIFU under 150 W and 250 W sound power respectively. The control group was treated by ordinary ultrasound for 2 min.
RESULTS
The inner cyst wall of hydatid treated with HIFU became curved, thicker, stiffer, white and less transparent. The germinal layer was detached mostly from the laminated layers of hydatid in the experiment groups. Images from the transmission electron microscopy showed that in the experiment groups fabric texture of hydatid changed significantly and germinal cells were broken.
CONCLUSION
HIFU in a model of cyclical multilayer radiation causes pathological damage of the E. granulosus hydatid.
目的
研究高强度聚焦超声（HIFU）治疗细粒棘球绦虫包虫囊肿的病理变化。
方法
从感染羊的肝脏中选取30个壁薄且弹性适中的囊肿，随机分为三组。通过在囊肿壁周围进行周期性多层辐射，两个实验组分别在150W和250W声功率下用HIFU治疗。对照组用普通超声治疗2分钟。
结果
HIFU治疗后的包虫内囊壁变得弯曲、增厚、变硬、呈白色且透明度降低。实验组中生发层大多从包虫的层状层分离。透射电子显微镜图像显示，实验组中包虫的组织结构发生显著变化，生发细胞破裂。
结论
在周期性多层辐射模型中，HIFU会导致细粒棘球绦虫包虫发生病理损伤。
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