Luo Yan-Rui, Li Xiao-Yu, Chen Xiao-Xiao, Zhang Bang-Jun, Sun Zhen-Jun, Wang Jian-Ji
College of Resources and Environmental Sciences, China Agricultural University, Beijing 100094, China.
Environ Toxicol. 2008 Dec;23(6):736-44. doi: 10.1002/tox.20382.
The developmental toxicity of 1-methyl-3-octylimidazolium bromide ([C(8)mim]Br) on Daphnia magna was investigated. The 24 and 48 h LC(50) values for [C(8)mim]Br in D. magna were 1.99 and 0.95 mg/L, respectively. A series of multigenerational toxicity tests were then used to explore [C(8)mim]Br effects in D. magna. [C(8)mim]Br significantly inhibited the body lengths of the F0 and F1 1st generations. After 21 days of exposure, [C(8)mim]Br lowered the reproductive ability of the F0 and F1 1st generations. In F1 3rd generation, 21 days of [C(8)mim]Br exposure prolonged the time to bear the first egg and the time to the first brood compared with the control, but the number of first-brood offspring and the number of broods produced by these animals were reduced. After the recovery period all the reproductive parameters returned to normal in F1 1st generation except for the number of broods. The dead neonates increased with prolonged exposure and increasing concentrations, and the dead neonates of the F1 3rd generation went far beyond that of the F1 1st and F0 generations. The intrinsic rate of natural increase (r) values of the three D. magna generations significantly decreased after exposure to higher concentrations of [C(8)mim]Br compared with control groups. Collectively, these results suggest that [C(8)mim]Br exerts a toxic effect on the development of D. magna. This study also highlights the importance of systematically evaluating the potential effects of aquatic ecosystems of ionic liquids that may be released into bodies of water.
研究了1-甲基-3-辛基咪唑溴盐（[C(8)mim]Br）对大型溞的发育毒性。[C(8)mim]Br对大型溞的24小时和48小时半数致死浓度（LC(50)）值分别为1.99毫克/升和0.95毫克/升。随后进行了一系列多代毒性试验，以探究[C(8)mim]Br对大型溞的影响。[C(8)mim]Br显著抑制了F0和F1第一代的体长。暴露21天后，[C(8)mim]Br降低了F0和F1第一代的繁殖能力。在F1第三代中，与对照组相比，暴露于[C(8)mim]Br 21天延长了首次产卵时间和首次繁殖时间，但这些动物的首次繁殖后代数量和繁殖窝数减少。恢复期后，除繁殖窝数外，F1第一代的所有生殖参数均恢复正常。随着暴露时间延长和浓度增加，死亡幼体数量增加，F1第三代的死亡幼体数量远远超过F1第一代和F0代。与对照组相比，暴露于较高浓度的[C(8)mim]Br后，大型溞三代的内禀增长率（r）值显著降低。总体而言，这些结果表明[C(8)mim]Br对大型溞的发育具有毒性作用。本研究还强调了系统评估可能释放到水体中的离子液体对水生生态系统潜在影响的重要性。
