Egreteau J P, Guedes Y, L'Azou D
Département d'anesthésie-réanimation chirurgicale, Centre hospitalier et universitaire de Brest.
Agressologie. 1991;32(8-9 Spec No):455-9.
Pharmacokinetics of anesthetic drugs are widely influenced by their physical properties. Lipo-solubility is the most important characteristic. This parameter conditions tissue diffusion and subsequently potency and duration of action drugs Distribution is unequal in the different compartments of the body. The concept of effective compartment allows a best understanding of relationship between concentration, intensity and duration of action of anesthetic drugs. Constant intravenous infusion route of anesthetic drugs administration requires to be discussed.
麻醉药物的药代动力学受到其物理性质的广泛影响。脂溶性是最重要的特性。该参数决定了组织扩散，进而影响药物的效力和作用持续时间。药物在身体的不同腔室中分布不均。有效腔室的概念有助于更好地理解麻醉药物的浓度、强度和作用持续时间之间的关系。麻醉药物持续静脉输注给药途径需要进行讨论。
