Chaniary Kunal, Baron Mark, Rice Ann, Wetzel Paul, Shapiro Steven
Biomedical Engineering, Virginia Commonwealth University, Richmond, Virginia, USA.
Mov Disord. 2008 Jun 15;23(8):1122-9. doi: 10.1002/mds.22040.
Kernicterus is known to produce damage to the auditory system and the basal ganglia in humans. Although the Gunn rat model of kernicterus has been extensively used to characterize the auditory features, this model has not been similarly utilized to systematically investigate the movement disorder. In the present study, spontaneously jaundiced (jj) 16 day old Gunn rat pups were treated with sulfadimethoxine to exacerbate bilirubin toxicity and compared to saline treated jjs and non-jaundiced (Nj) littermates. Electromyographic (EMG) activity was recorded from antagonistic hip muscles in dystonic and in normal appearing rats. Raw EMG signals were decomposed using the Discrete Wavelet Transform based multi-resolution analysis and signal coefficients corresponding to the dominant EMG frequency band were chosen. Gunn rats exposed to sulfadimethoxine developed a stable clinical state characterized by prolonged abnormal axial and appendicular postures. Coherence plots of the separated signals coefficients revealed 4-7 Hz co-activation in antagonistic muscles that was significantly more prominent in jj sulfa treated dystonic compared to normal rats. The EMG findings support the presence of dystonia in sulfadimethoxine exposed jj Gunn rats and suggest that these animals can serve as a valuable model for experimental investigations of dystonia.
核黄疸已知会对人类听觉系统和基底神经节造成损害。尽管核黄疸的冈恩大鼠模型已被广泛用于描述听觉特征，但该模型尚未被类似地用于系统研究运动障碍。在本研究中，对16日龄自发黄疸（jj）的冈恩大鼠幼崽用磺胺二甲氧嘧啶进行处理，以加重胆红素毒性，并与用生理盐水处理的jj大鼠和非黄疸（Nj）同窝大鼠进行比较。记录了张力障碍大鼠和外观正常大鼠拮抗髋部肌肉的肌电图（EMG）活动。使用基于离散小波变换的多分辨率分析对原始EMG信号进行分解，并选择对应于主要EMG频带的信号系数。暴露于磺胺二甲氧嘧啶的冈恩大鼠发展出一种稳定的临床状态，其特征为异常的轴向和附属姿势持续时间延长。分离信号系数的相干图显示，拮抗肌中存在4-7Hz的共同激活，与正常大鼠相比，jj磺胺处理的张力障碍大鼠中这种激活明显更显著。EMG结果支持暴露于磺胺二甲氧嘧啶的jj冈恩大鼠存在肌张力障碍，并表明这些动物可作为肌张力障碍实验研究的有价值模型。
