Wu Long, Liu Xiaojun, Li Ding
Department of Biology and Chemistry, City University of Hong Kong, Hong Kong SAR, P.R. China.
Org Lett. 2008 Jun 5;10(11):2235-8. doi: 10.1021/ol800606r. Epub 2008 Apr 29.
Oct-2-yn-4-enoyl-CoA was found to be a multifunctional irreversible enzyme inhibitor in fatty acid oxidation mainly targeting mitochondrial trifunctional protein beta-subunit. It can also inactivate enoyl-CoA hydratase 2 and medium-chain acyl-CoA dehydrogenase. This study increased our understanding for the effect of acetylenic acids on fatty acid oxidation.
发现10-2-炔-4-烯酰辅酶A是脂肪酸氧化过程中的一种多功能不可逆酶抑制剂，主要作用于线粒体三功能蛋白β亚基。它还能使烯酰辅酶A水合酶2和中链酰基辅酶A脱氢酶失活。这项研究增进了我们对炔酸对脂肪酸氧化作用的理解。
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