Wu Long, Lin Shuping, Li Ding
Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, P. R. China.
Org Lett. 2008 Aug 7;10(15):3355-8. doi: 10.1021/ol801267e. Epub 2008 Jul 9.
Enoyl-CoA hydratase 1 and enoyl-CoA hydratase 2 in long-chain fatty acid oxidation were comparatively investigated through mechanistic studies for inactivation of the enzymes with methylenecyclopropylformyl-CoA and 3-octynoyl-CoA. Methylenecyclopropylformyl-CoA can inactivate both enzymes, while 3-octynoyl-CoA inactivates enoyl-CoA hydratase 2 only. The study increased our understanding of these two enzymes in fatty acid oxidation.
通过用亚甲基环丙基甲酰辅酶A和3-辛炔酰辅酶A使酶失活的机理研究，对长链脂肪酸氧化中的烯酰辅酶A水合酶1和烯酰辅酶A水合酶2进行了比较研究。亚甲基环丙基甲酰辅酶A可使这两种酶失活，而3-辛炔酰辅酶A仅使烯酰辅酶A水合酶2失活。该研究增进了我们对脂肪酸氧化中这两种酶的理解。
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