Rudzka E, Holowiecki J, Kachel L, Lawniczek T, Pajak J
Clinic of Haematology, Katowice, Poland.
Haematologia (Budap). 1991;24(4):235-9.
In the group of 75 ALL patients treated between 1980 and 1989, two women (ages 25 and 17, both FAB-L2 and CALLA +, after 56 and 34 months of continuous CR, respectively) were found to have a relapse manifested as a local infiltration of skin, with involvement of the adjacent lymph nodes in one patient. The leukaemic character of the skin infiltration was confirmed by skin needle aspiration and tissue biopsy expressing CD10 and CD24. Both patients were given intensified systemic chemotherapy and local X-ray irradiation. Complete remission was obtained with the disappearance of the skin infiltrations followed after 13 and 8 months, respectively, followed by a marrow relapse with symptoms of CNS involvement in one case. Both patients died because of treatment resistance (the overall survival time equalled 70 and 44 months, respectively).
在1980年至1989年接受治疗的75例急性淋巴细胞白血病患者中，两名女性（年龄分别为25岁和17岁，均为FAB-L2型且CALLA阳性，分别持续完全缓解56个月和34个月后）出现复发，表现为皮肤局部浸润，其中一名患者伴有邻近淋巴结受累。皮肤穿刺活检及组织活检显示表达CD10和CD24，证实了皮肤浸润的白血病特征。两名患者均接受了强化全身化疗及局部X线照射。皮肤浸润分别在13个月和8个月后消失，获得完全缓解，随后其中1例出现骨髓复发并伴有中枢神经系统受累症状。两名患者均因治疗抵抗死亡（总生存时间分别为70个月和44个月）。
