Weigert Johanna, Neumeier Markus, Wanninger Josef, Wurm Sylvia, Kopp Andrea, Schober Franziska, Filarsky Michael, Schäffler Andreas, Zeitoun Martina, Aslanidis Charalampos, Buechler Christa
Department of Internal Medicine I, Regensburg University Hospital, Regensburg, Germany.
FEBS Lett. 2008 May 28;582(12):1777-82. doi: 10.1016/j.febslet.2008.04.031. Epub 2008 Apr 28.
The abundance of the adiponectin receptors, AdipoR1 and AdipoR2, and the effects of the antidiabetic adipokine adiponectin in monocytes of normal-weight and overweight controls and type 2 diabetic patients (T2D) were analyzed. AdipoR1 and AdipoR2 mRNAs were increased in monocytes of obese controls and T2D patients when compared to normal-weight controls, and AdipoR1 mRNA positively correlated to AdipoR2 mRNA, the waist to hip ratio and systemic adiponectin. However, AdipoR1 and AdipoR2 proteins were lower in monocytes of T2D compared to normal-weight donors. Induction of IL-6 and IL-8 by adiponectin, an effect involving p38 MAPK, was also reduced in T2D monocytes.
分析了脂联素受体AdipoR1和AdipoR2的丰度，以及抗糖尿病脂肪因子脂联素对正常体重和超重对照者及2型糖尿病患者（T2D）单核细胞的影响。与正常体重对照者相比，肥胖对照者和T2D患者单核细胞中的AdipoR1和AdipoR2 mRNA水平升高，且AdipoR1 mRNA与AdipoR2 mRNA、腰臀比和全身脂联素呈正相关。然而，与正常体重供体相比，T2D患者单核细胞中的AdipoR1和AdipoR2蛋白水平较低。脂联素诱导IL-6和IL-8（一种涉及p38丝裂原活化蛋白激酶的效应）在T2D单核细胞中也有所降低。
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