Robinson B H, Oei J
Pediatr Res. 1976 Oct;10(10):819-23. doi: 10.1203/00006450-197610000-00001.
The activities of key gluconeogenic enzymes in the livers of newborn guinea pigs were monitored as a function of time following birth either vaginally at term or prematurely by cesarian section at 62 days of gestation. The activity of hepatic glucose-6-phosphatase rose dramatically from 1.40 +/- 0.26 mumol/min/g at birth to a maximum of 6.8 +/- 0.9 mumol/min/g at 24 hr in prematurely delivered animals although there was little significant change in activity in full term animals. The activity of hepatic fructose-1,6-diphosphatase and mitochondrial phosphoenolpyruvate carboxykinase changed little over the first 3 days of life in either full term or premature animals. Cytosolic phosphoenolpyruvate carboxykinase, on the other hand, had low activity at birth being 0.11 +/- 0.03 mumol/min/g in full term and 0.06 +/- 0.04 mumol in premature animals rising to values of 0.71 +/- 0.06 and 1.12 +/- 0.12 mumol/min/g, respectively, at 24 hr of life. Pyruvate carboxylase activities in the premature animals remained significantly lower than those in full term animals in the first 72 hr of life. Transient hypoglycemia was evident in the prematurely delivered animals, but not in the full term animals, the blood glucose values being 82 +/- 7 mg/100 ml for the full term animals and 20 +/- 8 mg/100 ml for the premature infants at 2 hr of life.
对新生豚鼠肝脏中关键糖异生酶的活性进行了监测，这些豚鼠要么是足月经阴道分娩，要么是在妊娠62天时通过剖宫产早产。在早产动物中，肝葡萄糖-6-磷酸酶的活性从出生时的1.40±0.26微摩尔/分钟/克急剧上升至出生后24小时的最高值6.8±0.9微摩尔/分钟/克，而足月动物的活性几乎没有显著变化。在足月或早产动物出生后的头3天里，肝果糖-1,6-二磷酸酶和线粒体磷酸烯醇式丙酮酸羧激酶的活性变化不大。另一方面，胞质磷酸烯醇式丙酮酸羧激酶在出生时活性较低，足月动物为0.11±0.03微摩尔/分钟/克，早产动物为0.06±0.04微摩尔，在出生后24小时分别升至0.71±0.06和1.12±0.12微摩尔/分钟/克。早产动物的丙酮酸羧化酶活性在出生后的头72小时内仍显著低于足月动物。早产动物出现短暂性低血糖，而足月动物没有，足月动物出生后2小时的血糖值为82±7毫克/100毫升，早产动物为20±8毫克/100毫升。
