Dhanotiya R S, Bhardwaj R
Department of Biochemistry, University of Indore, India.
Biomed Biochim Acta. 1988;47(8):805-8.
The development of three key gluconeogenic enzymes, viz. phosphoenolpyruvate carboxykinase, fructose 1.6-bisphosphatase and glucose 6-phosphatase, and the gluconeogensis by liver slices were studied during development of goat fetus. The three enzymes develop in a sequential and time dependent manner, and the glucose 6-phosphatase develops last at around 100 days of gestation. Glucose synthesis by fetal liver slices was observed after 120 days of gestation. It may be concluded that the gluconeogenic sequence is operative well before birth and the goat fetus synthesizes its own glucose after 100 days of gestation.
在山羊胎儿发育过程中，研究了三种关键的糖异生酶，即磷酸烯醇丙酮酸羧激酶、果糖1,6 -二磷酸酶和葡萄糖6 -磷酸酶，以及肝切片的糖异生作用。这三种酶以顺序和时间依赖的方式发育，葡萄糖6 -磷酸酶在妊娠约100天时最后发育。妊娠120天后观察到胎儿肝切片合成葡萄糖。可以得出结论，糖异生序列在出生前就有效运作，山羊胎儿在妊娠100天后合成自身的葡萄糖。
