Ma Yao-Ying, Shi Xiang-Dang, Han Ji-Sheng, Cui Cai-Lian
Neuroscience Research Institute, Peking University, 38 Xueyuan Road, Beijing 100083, PR China.
Brain Res. 2008 May 30;1212:63-70. doi: 10.1016/j.brainres.2008.03.044. Epub 2008 Apr 1.
In the previous study we reported that morphine-induced conditioned place preference (CPP) could be suppressed by peripheral electric stimulation (PES), an effect related to the increased gene expression of opioid peptides in the central nervous system. Considering that opioids were known to elevate dopamine (DA) activity in the mesolimbic brain, the present study was designed to further analyze the possible involvement of the mesolimbic dopaminergic system (MLDS) in the suppressive effect of PES on the rewarding effects of morphine in SD male rats. We found that morphine-induced CPP can be successfully suppressed by PES, an effect accompanied by a reversal of the increased tissue contents of DA and its metabolites in the nucleus accumbens (NAc) of morphine-induced CPP rats. Our results suggest that MLDS seems to play important roles in the mechanisms underlying PES's suppression of the rewarding effect of drug-associated environmental cues in the rat.
在先前的研究中，我们报道外周电刺激（PES）可抑制吗啡诱导的条件性位置偏爱（CPP），这一效应与中枢神经系统中阿片肽基因表达增加有关。鉴于已知阿片类药物会提高中脑边缘系统的多巴胺（DA）活性，本研究旨在进一步分析中脑边缘多巴胺能系统（MLDS）在PES对SD雄性大鼠吗啡奖赏效应的抑制作用中可能发挥的作用。我们发现，PES能够成功抑制吗啡诱导的CPP，这一效应伴随着吗啡诱导的CPP大鼠伏隔核（NAc）中DA及其代谢产物组织含量增加的逆转。我们的结果表明，MLDS似乎在PES抑制大鼠药物相关环境线索奖赏效应的潜在机制中发挥重要作用。
