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用99m锝标记的抗癌胚抗原BW 431/26单克隆抗体进行胃肿瘤的免疫闪烁显像

[Immunoscintigraphy in stomach neoplasms with anti-CEA BW 431/26 monoclonal antibodies marked with Tc 99 m].

作者信息

González P, Escobar M I, Csendes A, Lillo R, Fodor M, Guzmán G, Baum R P, Massardo T, Gaínza V, Otárola S

机构信息

Departamento de Cirugía, Hospital Clínico de la Universidad de Chile, Santiago de Chile.

出版信息

Rev Med Chil. 1991 May;119(5):572-6.

PMID:1844299
Abstract

A 57 year old female had a tubular gastric adenocarcinoma confirmed by endoscopy and radiologic studies. Echotomography of the abdomen revealed multiple adenopathies. Immunoscintigraphy with 99mTc labeled anti-CEA BW 431/26 monoclonal antibody was performed. Images obtained at 6 and 24 h showed a significant uptake at the primary lesion and at periaortic adenopathies both in conventional gamma-camera and single emission photon tomography. This immuno-scintigraphic technique may be helpful in the management of patients with gastric cancer.

摘要

一名57岁女性经内镜检查和放射学研究确诊为管状胃腺癌。腹部超声断层扫描显示多处淋巴结肿大。采用99mTc标记的抗癌胚抗原BW 431/26单克隆抗体进行免疫闪烁显像。在6小时和24小时获得的图像显示,在原发性病变部位以及主动脉旁淋巴结肿大处,常规γ相机和单光子发射断层扫描均显示有明显摄取。这种免疫闪烁显像技术可能有助于胃癌患者的管理。

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