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对左旋沙丁胺醇的矛盾反应。

Paradoxical response to levalbuterol.

作者信息

Broski Sarah E, Amundson Dennis E

机构信息

Pulmonary and Critical Care Department, Naval MedicalCenter San Diego, San Diego, Calif., USA.

出版信息

J Am Osteopath Assoc. 2008 Apr;108(4):211-3.

Abstract

Asthma is a common condition that can substantially affect patients' quality of life. Although several drugs, most commonly beta-adrenergic agonists, alleviate symptoms of asthma, they may cause paradoxical bronchospasm or paradoxical bronchoconstriction. Levalbuterol hydrochloride-a pure form of the (R)-stereoisomer in racemic albuterol-eliminates the adrenergic properties that can cause such adverse effects. However, we report a case of paradoxical bronchoconstriction in a 36-year-old man who was recently diagnosed as having new-onset asthma and was treated with levalbuterol.

摘要

哮喘是一种常见病症,会严重影响患者的生活质量。尽管有多种药物,最常见的是β-肾上腺素能激动剂,可缓解哮喘症状,但它们可能会引发矛盾性支气管痉挛或矛盾性支气管收缩。盐酸左沙丁胺醇——消旋沙丁胺醇中(R)-立体异构体的纯形式——消除了可能导致此类不良反应的肾上腺素能特性。然而,我们报告了一例36岁男性的矛盾性支气管收缩病例,该患者最近被诊断为新发哮喘并接受了左沙丁胺醇治疗。

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