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矛盾性支气管痉挛:使用非诺特罗的一种罕见不良反应。

Paradoxical bronchospasm: a rare adverse effect of fenoterol use.

作者信息

Lai Ching-Han, Liao Xin-Min

机构信息

Division of Pulmonary Medicine, Department of Internal Medicine National Cheng Kung University Hospital Tainan Taiwan.

出版信息

Respirol Case Rep. 2021 Mar 17;9(4):e00698. doi: 10.1002/rcr2.698. eCollection 2021 Apr.

Abstract

Paradoxical bronchospasm refers to the constriction of the airways after treatment with a sympathomimetic bronchodilator. Theoretically, bronchodilators, such as beta-agonist inhalers, act to ease asthma symptoms by relaxing the muscles surrounding the walls of the bronchial tubes, which relieve bronchial constriction. However, in rare instances, some patients develop respiratory distress or even respiratory failure after inhaled bronchodilator use, although the exact mechanism for this adverse effect is unknown. We report a male, with a known asthma history diagnosed for more than one decade, receiving fenoterol (Berotec®) for wheezing control and the worsening of his clinical condition immediately after bronchodilator administration.

摘要

矛盾性支气管痉挛是指在用拟交感神经支气管扩张剂治疗后气道出现收缩。从理论上讲,支气管扩张剂,如β受体激动剂吸入器,通过放松支气管管壁周围的肌肉来缓解哮喘症状,从而减轻支气管收缩。然而,在极少数情况下,一些患者在使用吸入性支气管扩张剂后会出现呼吸窘迫甚至呼吸衰竭,尽管这种不良反应的确切机制尚不清楚。我们报告一例男性患者,有超过十年的哮喘病史,使用非诺特罗(备劳特®)控制喘息,在使用支气管扩张剂后临床状况立即恶化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70ea/7967704/eccebd8850b4/RCR2-9-e00698-g001.jpg

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