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DNA replication timing of the human beta-globin domain is controlled by histone modification at the origin.
Genes Dev. 2008 May 15;22(10):1319-24. doi: 10.1101/gad.468308. Epub 2008 Apr 28.
2
Developmentally dynamic histone acetylation pattern of a tissue-specific chromatin domain.
Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14494-9. doi: 10.1073/pnas.97.26.14494.
3
"Maturational" globin switching in primary primitive erythroid cells.
Blood. 2006 Feb 15;107(4):1665-72. doi: 10.1182/blood-2005-08-3097. Epub 2005 Nov 1.
4
Shifts in replication timing actively affect histone acetylation during nucleosome reassembly.
Mol Cell. 2009 Jun 26;34(6):767-74. doi: 10.1016/j.molcel.2009.05.027.
5
Formation of a tissue-specific histone acetylation pattern by the hematopoietic transcription factor GATA-1.
Mol Cell Biol. 2003 Feb;23(4):1334-40. doi: 10.1128/MCB.23.4.1334-1340.2003.
9
Role of epigenetic modifications in normal globin gene regulation and butyrate-mediated induction of fetal hemoglobin.
Blood. 2007 Nov 1;110(9):3391-7. doi: 10.1182/blood-2007-02-076091. Epub 2007 Jul 17.

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1
Transcription can be sufficient, but is not necessary, to advance replication timing.
bioRxiv. 2025 Feb 5:2025.02.04.636516. doi: 10.1101/2025.02.04.636516.
2
KMT2C/KMT2D-dependent H3K4me1 mediates changes in DNA replication timing and origin activity during a cell fate transition.
Cell Rep. 2025 Feb 25;44(2):115272. doi: 10.1016/j.celrep.2025.115272. Epub 2025 Feb 4.
4
MLL3/MLL4 enzymatic activity shapes DNA replication timing.
bioRxiv. 2023 Dec 8:2023.12.07.569680. doi: 10.1101/2023.12.07.569680.
5
Multi-Scale Imaging of the Dynamic Organization of Chromatin.
Int J Mol Sci. 2023 Nov 4;24(21):15975. doi: 10.3390/ijms242115975.
6
Where and when to start: Regulating DNA replication origin activity in eukaryotic genomes.
Nucleus. 2023 Dec;14(1):2229642. doi: 10.1080/19491034.2023.2229642.
7
Replication timing and transcriptional control: beyond cause and effect - part IV.
Curr Opin Genet Dev. 2023 Apr;79:102031. doi: 10.1016/j.gde.2023.102031. Epub 2023 Mar 9.
8
The evolution of the human DNA replication timing program.
Proc Natl Acad Sci U S A. 2023 Mar 7;120(10):e2213896120. doi: 10.1073/pnas.2213896120. Epub 2023 Feb 27.
9
Origins of DNA replication in eukaryotes.
Mol Cell. 2023 Feb 2;83(3):352-372. doi: 10.1016/j.molcel.2022.12.024. Epub 2023 Jan 13.
10
Impact of Chromosomal Context on Origin Selection and the Replication Program.
Genes (Basel). 2022 Jul 14;13(7):1244. doi: 10.3390/genes13071244.

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2
Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer.
Nat Genet. 2007 Feb;39(2):232-6. doi: 10.1038/ng1950. Epub 2006 Dec 31.
3
Fine tuning of globin gene expression by DNA methylation.
PLoS One. 2006 Dec 20;1(1):e46. doi: 10.1371/journal.pone.0000046.
4
An origin of DNA replication in the promoter region of the human fragile X mental retardation (FMR1) gene.
Mol Cell Biol. 2007 Jan;27(2):426-37. doi: 10.1128/MCB.01382-06. Epub 2006 Nov 13.
5
Cell cycle dependent regulation of the origin recognition complex.
Cell Cycle. 2005 Jan;4(1):70-9. doi: 10.4161/cc.4.1.1333. Epub 2005 Jan 29.
6
Mechanisms involved in regulating DNA replication origins during the cell cycle and in response to DNA damage.
Philos Trans R Soc Lond B Biol Sci. 2004 Jan 29;359(1441):31-8. doi: 10.1098/rstb.2003.1362.
7
The human beta-globin replication initiation region consists of two modular independent replicators.
Mol Cell Biol. 2004 Apr;24(8):3373-86. doi: 10.1128/MCB.24.8.3373-3386.2004.
9
Replicating by the clock.
Nat Rev Mol Cell Biol. 2003 Jan;4(1):25-32. doi: 10.1038/nrm1008.
10
Histone acetylation regulates the time of replication origin firing.
Mol Cell. 2002 Nov;10(5):1223-33. doi: 10.1016/s1097-2765(02)00702-5.

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