Smith-Bouvier Deborah L, Divekar Anagha A, Sasidhar Manda, Du Sienmi, Tiwari-Woodruff Seema K, King Jennifer K, Arnold Arthur P, Singh Ram Raj, Voskuhl Rhonda R
Department of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
J Exp Med. 2008 May 12;205(5):1099-108. doi: 10.1084/jem.20070850. Epub 2008 Apr 28.
Most autoimmune diseases are more common in women than in men. This may be caused by differences in sex hormones, sex chromosomes, or both. In this study, we determined if there was a contribution of sex chromosomes to sex differences in susceptibility to two immunologically distinct disease models, experimental autoimmune encephalomyelitis (EAE) and pristane-induced lupus. Transgenic SJL mice were created to permit a comparison between XX and XY within a common gonadal type. Mice of the XX sex chromosome complement, as compared with XY, demonstrated greater susceptibility to both EAE and lupus. This is the first evidence that the XX sex chromosome complement, as compared with XY, confers greater susceptibility to autoimmune disease.
大多数自身免疫性疾病在女性中比在男性中更为常见。这可能是由性激素、性染色体或两者的差异所导致的。在本研究中，我们确定性染色体是否对两种免疫上不同的疾病模型——实验性自身免疫性脑脊髓炎（EAE）和 pristane 诱导的狼疮——易感性的性别差异有影响。构建了转基因 SJL 小鼠，以便在相同性腺类型内比较 XX 和 XY 小鼠。与 XY 小鼠相比，具有 XX 性染色体组成的小鼠对 EAE 和狼疮均表现出更高的易感性。这是首个证据表明，与 XY 相比，XX 性染色体组成赋予了对自身免疫性疾病更高的易感性。
Zotero 插件
