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盆腔因素不孕症:各种治疗方法的诊断与预后

Pelvic factor infertility: diagnosis and prognosis of various procedures.

作者信息

Bulletti Carlo, Panzini I, Borini A, Coccia E, Setti Paolo Levi, Palagiano Antonio

机构信息

Physiopathology of Reproduction, Cattolica's General Hospital and University of Bologna, Bologna, Italy.

出版信息

Ann N Y Acad Sci. 2008 Apr;1127:73-82. doi: 10.1196/annals.1434.020.

Abstract

Infertile women are examined to exclude tubal occlusion or a pelvic factor through indirect tests, such as hysterosalpingography (HSG), sonohysterosalpingography/hysterosalpingosonography (SH), and/or laparoscopy (Lps). Assisted reproductive technologies (ART) are proposed to resolve infertility according to the results of the above-mentioned diagnostic procedures. Today, Lps still represents the second option after several failures of in vivo attempts and before moving to conceive in vitro. The aim of this study was to establish the diagnostic power of HSG and SH compared with that of Lps and the efficacy of ART when each single test is used as an inclusion criterion. We recruited 2560 infertile women (aged 20 to 35) to undergo diagnostic and therapeutic procedures to address their infertility in our clinical theatre. Of these, 1080 women underwent Lps and hysteroscopy (Group 1), 525 underwent HSG (Group 2), and 955 underwent SH (Group 3). The positive and negative predictive values of sonosalpingosonography were 75.8% and 91.2% and those of hysterosalpingography were 71.8% and 88.2%, respectively. Endometriosis (stage II-IV of the revised American Society for Reproductive Medicine [ASRM] classification) was diagnosed laparoscopically in 344 out of 1080 women (32%). Only 44 women (13%) with endometriosis showed bilateral tubal occlusion. Pelvic factors other than tubal occlusions are neither diagnosed nor treated in a timely manner by indirect tubal patency tests. The conventional use of HSG and/or SH may increase the time required to find an adequate treatment by which to achieve a successful pregnancy.

摘要

对不孕女性进行检查,通过间接检查方法,如子宫输卵管造影(HSG)、超声子宫输卵管造影/子宫输卵管超声检查(SH)和/或腹腔镜检查(Lps),以排除输卵管阻塞或盆腔因素。根据上述诊断程序的结果,建议采用辅助生殖技术(ART)来解决不孕问题。如今,在多次体内受孕尝试失败后且尚未进行体外受孕之前,Lps仍然是第二种选择。本研究的目的是确定与Lps相比,HSG和SH的诊断能力,以及当每种单一检查用作纳入标准时ART的疗效。我们招募了2560名年龄在20至35岁之间的不孕女性,在我们的临床手术室接受诊断和治疗程序以解决她们的不孕问题。其中,1080名女性接受了Lps和宫腔镜检查(第1组),525名接受了HSG(第2组),955名接受了SH(第3组)。子宫输卵管超声检查的阳性和阴性预测值分别为75.8%和91.2%,子宫输卵管造影的阳性和阴性预测值分别为71.8%和88.2%。在1080名女性中,有344名(32%)经腹腔镜检查诊断为子宫内膜异位症(根据美国生殖医学学会[ASRM]修订分类的II-IV期)。只有44名(13%)患有子宫内膜异位症的女性出现双侧输卵管阻塞。间接输卵管通畅性检查无法及时诊断和治疗除输卵管阻塞以外的盆腔因素。常规使用HSG和/或SH可能会增加找到实现成功妊娠的适当治疗方法所需的时间。

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