Ben Hamida Nouaili Emira, Harouni Makrem, Chaouachi Sihem, Sfar Rachida, Marrakchi Zahra
Service de néonatologie, Hôpital Charles Nicolle, Tunis, Tunisie.
Tunis Med. 2008 Feb;86(2):136-9.
Early-onset neonatal bacterial infections continue to be a major cause of morbidity and mortality in the newborn. THE AIM of this study was to determine the incidene, the risk factors and bacterial epidemiology of these infections.
All cases of early-onset neonatal bacterial infections were identified for the years 2001-2003 using data from obstetric and neonatal reports at the neonatal unit of Charles Nicolle Hospital.
144 cases were identified over 11,201 live births, that is an incidence of 12.85 per thousand, of which 22 cases of sepsis infections. 22.9% of all newborns were premature and 18% had a low birth weight. Membrane rupture occurred more than 12 hours before delivery in 63.2% of cases and an intra-partum fever in 57.7% of cases. Half of newborns were symptomatic with a mean age of 7.5 hours at onset of symptomatology. The principal etiologic agents were Group B Streptococcus (GBS) and Escherichia coli (E.coli), responsible respectively of 50% and 29.1% of proved infections. GBS had been recognised as the most prevalent agent in term newborn (58.9%) and the E.coli in premature newborn (38.5%). The neonatal mortality before discharge was 2.77% of all cases.
Neonatal bacterial infections continue to be a major cause of morbidity in the newborn. The most common etiologic agents remain GBS and E. coli.
早发型新生儿细菌感染仍然是新生儿发病和死亡的主要原因。本研究的目的是确定这些感染的发病率、危险因素和细菌流行病学。
利用查尔斯·尼科勒医院新生儿科的产科和新生儿报告数据，确定2001年至2003年期间所有早发型新生儿细菌感染病例。
在11201例活产中确定了144例，发病率为千分之12.85，其中22例为败血症感染。所有新生儿中22.9%为早产儿，18%为低体重儿。63.2%的病例胎膜破裂发生在分娩前12小时以上，57.7%的病例有产时发热。一半的新生儿有症状，症状出现时的平均年龄为7.5小时。主要病原体是B族链球菌（GBS）和大肠杆菌（E.coli），分别占确诊感染的50%和29.1%。GBS被认为是足月儿中最常见的病原体（58.9%），大肠杆菌是早产儿中最常见的病原体（38.5%）。出院前的新生儿死亡率为所有病例的2.77%。
新生儿细菌感染仍然是新生儿发病的主要原因。最常见的病原体仍然是GBS和大肠杆菌。
