同步双侧乳腺癌的临床病理特征。30例患者的报告。

Clinicopathological characteristics of synchronous bilateral breast carcinomas. Report of 30 patients.

作者信息

Ben Hassouna Jamel, Damak Tarak, Chargui Riadh, Slimene Maher, Chkir Amine, Ayadi Mohamed Ali, Mtallah Mohamed, Hechiche Monia, Gamoudi Amor, Khomsi Fethi, Ben Dhiab Tarak, Rahal Khaled

机构信息

Department of surgical oncology, Salah Azaiz Institute, Tunis, Tunisie.

出版信息

Tunis Med. 2008 Feb;86(2):155-9.

PMID:18444533

Abstract

AIM

The objective of this study is to determine the clinicopathologic characteristics; incidence and prognosis value of synchronous bilateral breast carcinoma (SBBC).

METHODS

This is a retrospective study done in Salah Azaiz Institute of Tunis about 30 patients with synchronous bilateral breast carcinomas diagnosed and treated over a 21-years period going from 1977 to 1997. The definition of synchronous breast lesions is the developpement of the contralateral breast cancer within 6 months.

RESULTS

Median age was 49 years. The incidence of SBBC was 0.52%. History family was noted in 3% of our population. Mean tumor size was 40 mm (15-145). Breast conserving therapy was done in 16% of cases (9 patients). Five-year overall survival was 40%. Five year survival rates were 72 and 17% for stage II and III, respectively. Main prognostic factors for survival were lymph node involvement (P=0.004) and disease stage (P=0.02).

CONCLUSION

Synchronous bilateral breast carcinoma is a rare entity, with a problem of definition concerning the delay of bilaterlisation. Their prognosis is similar to that of unilateral breast carcinoma patients of equal stage. Hence, breast conserving therapy can be used s fely if indicated.

摘要

目的

本研究的目的是确定同步双侧乳腺癌（SBBC）的临床病理特征、发病率及预后价值。

方法

这是一项在突尼斯萨拉赫·阿扎伊兹研究所进行的回顾性研究，涉及1977年至1997年期间诊断并治疗的30例同步双侧乳腺癌患者。同步乳腺病变的定义为对侧乳腺癌在6个月内发生。

结果

中位年龄为49岁。SBBC的发病率为0.52%。3%的患者有家族史。平均肿瘤大小为40毫米（15 - 145）。16%的病例（9例患者）接受了保乳治疗。5年总生存率为40%。II期和III期的5年生存率分别为72%和17%。生存的主要预后因素是淋巴结受累（P = 0.004）和疾病分期（P = 0.02）。