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在社区环境中使用褪黑素治疗智障成年人的睡眠障碍——使用活动记录仪对三例病例的评估

The use of melatonin to treat sleep disorder in adults with intellectual disabilities in community settings - the evaluation of three cases using actigraphy.

作者信息

Dodd A, Hare D J, Arshad P

机构信息

Pennine Care NHS Trust, UK.

出版信息

J Intellect Disabil Res. 2008 Jun;52(Pt 6):547-53. doi: 10.1111/j.1365-2788.2008.01063.x. Epub 2008 Apr 28.

Abstract

BACKGROUND

Sleep disorders are known to be very prevalent in adults with intellectual disabilities (ID) but to date there has been limited objective assessment of either sleep disorders or of interventions such as the use of melatonin.

METHODOLOGY

A protocol-driven assessment and intervention procedure was followed with three people with moderate to severe ID identified as having a possible sleep disorder. Actigraphic assessment was used to determine the nature of the sleep disorder, after which sleep hygiene advice and then individual treatment with melatonin were provided, following which further actigraphic assessment was carried out. Behavioural disturbance was formally assessed before and after the intervention phase.

RESULTS

Following treatment with melatonin, changes in circadian rhythm were noted, together with improvements in challenging behaviour, but no significant effects were noted with regard to either quantity or quality of sleep.

CONCLUSIONS

A standardised procedure for assessment and treatment of sleep disorders in people with ID was established. Although no apparent effects on sleep quantity or quality were noted, this may reflect factors inherent in the sample, rather than the relative efficacy of melatonin treatment per se.

摘要

背景

睡眠障碍在成年智力障碍者中非常普遍,但迄今为止,对睡眠障碍或褪黑素使用等干预措施的客观评估有限。

方法

对三名被确定可能患有睡眠障碍的中度至重度智力障碍者采用了方案驱动的评估和干预程序。使用活动记录仪评估来确定睡眠障碍的性质,之后提供睡眠卫生建议,然后进行褪黑素个体化治疗,之后再进行进一步的活动记录仪评估。在干预阶段前后对行为障碍进行了正式评估。

结果

褪黑素治疗后,观察到昼夜节律变化,具有挑战性的行为也有所改善,但在睡眠数量或质量方面未观察到显著影响。

结论

建立了针对智力障碍者睡眠障碍的标准化评估和治疗程序。虽然未观察到对睡眠数量或质量有明显影响,但这可能反映了样本固有的因素,而非褪黑素治疗本身的相对疗效。

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