O'Leary Michael P, Wei John T, Roehrborn Claus G, Miner Martin
Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.
BJU Int. 2008 Jun;101(12):1531-5. doi: 10.1111/j.1464-410X.2008.07574.x. Epub 2008 Apr 28.
To evaluate the association between the International Prostate Symptom Score (IPSS) bother question (BQ) and a validated disease-specific quality-of-life questionnaire, the Benign Prostatic Hyperplasia (BPH) Impact Index (BPH-II), using the BPH Registry and Patient Survey database.
The BPH Registry and Patient Survey is a multicentre, longitudinal, observational database of management practices and patient outcomes in a population of patients with BPH in the USA, managed with watchful waiting or pharmacotherapy. Men enrolled in the BPH Registry who completed the IPSS BQ and the four-item BPH-II at enrolment were identified. The association between the IPSS BQ score and the BPH Impact Index was assessed using Spearman rank correlation.
At baseline (enrolment visit), 6439 men (mean age 66 years) completed the IPSS BQ and the BPH-II. The mean (sd) score of the IPSS BQ was 2.5 (1.4) and of the BPH-II was 2.8 (2.8). Based on responses to the BPH-II, at least half the men reported that their urinary symptoms were associated with physical discomfort, worry about their health, and bothersomeness. The IPSS BQ score was significantly correlated (P < 0.001) with the BPH-II (r = 0.68) and each of its four questions (physical discomfort, r = 0.52; worry about health, r = 0.53; bothersomeness of trouble with urination, r = 0.67; and time kept from usual activities, r = 0.44).
The IPSS BQ score has a strong and positive correlation with the BPH-II among men enrolled in the BPH Registry. The IPSS BQ is a convenient tool for assessing disease-specific quality of life when determining treatment strategies and evaluating treatment outcomes in men with BPH.
利用良性前列腺增生（BPH）注册登记与患者调查数据库，评估国际前列腺症状评分（IPSS）困扰问题（BQ）与经过验证的疾病特异性生活质量问卷——良性前列腺增生影响指数（BPH-II）之间的关联。
BPH注册登记与患者调查是一个多中心、纵向、观察性数据库，记录了美国BPH患者群体的管理实践和患者预后情况，这些患者接受观察等待或药物治疗。确定了在BPH注册登记中登记并在入组时完成IPSS BQ和四项BPH-II的男性。使用Spearman等级相关性评估IPSS BQ评分与BPH影响指数之间的关联。
在基线（入组访视）时，6439名男性（平均年龄66岁）完成了IPSS BQ和BPH-II。IPSS BQ的平均（标准差）评分为2.5（1.4），BPH-II的平均（标准差）评分为2.8（2.8）。根据对BPH-II的回答，至少一半的男性报告称他们的泌尿症状与身体不适、对健康的担忧以及困扰有关。IPSS BQ评分与BPH-II显著相关（P < 0.001）（r = 0.68）及其四个问题中的每一个（身体不适，r = 0.52；对健康的担忧，r = 0.53；排尿问题的困扰，r = 0.67；以及日常活动受限时间，r = 0.44）。
在参加BPH注册登记的男性中，IPSS BQ评分与BPH-II具有强烈的正相关。在确定BPH男性的治疗策略和评估治疗效果时，IPSS BQ是评估疾病特异性生活质量的便捷工具。
