Wittmann G
Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary.
J Neuroendocrinol. 2008 Jul;20(7):952-60. doi: 10.1111/j.1365-2826.2008.01748.x. Epub 2008 Apr 28.
Hypophysiotrophic corticotrophin-releasing hormone (CRH)- and thyrotrophin-releasing hormone (TRH)-synthesising neurones are the principal hypothalamic regulators of glucocorticoid and thyroid hormone secretion, respectively. These two neuroendocrine cell populations are closely situated in the hypothalamic paraventricular nucleus and are targets of neuronal afferent pathways that convey important signals for adapting the neurosecretory activity of CRH and TRH neurones to actual demands. The catecholaminergic afferents of CRH and TRH neurones originate from both noradrenaline- and adrenaline-synthesising cell groups located in the brainstem, and collectively represent one of the most well studied neural inputs of these neurones. The present review summarises the data obtained in recent years concerning the functional significance of the catecholaminergic innervation of hypophysiotrophic CRH and TRH neurones in rats.
促垂体促肾上腺皮质激素释放激素（CRH）和促甲状腺激素释放激素（TRH）合成神经元分别是下丘脑调节糖皮质激素和甲状腺激素分泌的主要神经元。这两类神经内分泌细胞群紧密位于下丘脑室旁核，并且是神经元传入通路的靶点，这些传入通路传递重要信号，使CRH和TRH神经元的神经分泌活动适应实际需求。CRH和TRH神经元的儿茶酚胺能传入神经起源于脑干中合成去甲肾上腺素和肾上腺素的细胞群，共同代表了这些神经元研究最为深入的神经输入之一。本综述总结了近年来关于大鼠促垂体CRH和TRH神经元儿茶酚胺能神经支配功能意义的研究数据。
