Willaime-Morawek Sandrine, van der Kooy Derek
Department of Molecular Genetics, University of Toronto, CCBR, Toronto, ON, Canada.
Eur J Neurosci. 2008 May;27(9):2354-62. doi: 10.1111/j.1460-9568.2008.06206.x.
Neural stem cells can be isolated from the mouse embryonic cortex but do not persist in the adult cortex. In contrast, neural stem cells from the striatal embryonic germinal zone persist in the adult subependyma. Emx1-lineage analysis revealed that cortex-derived neural stem cells survive and migrate ventrally into the subependyma where they intermix with the host striatal neural stem cells [S. Willaime-Morawek et al. (2006)J. Cell Biol. 175, 159-168]. Cortex-derived cells proliferate faster in the subependyma and reach the olfactory bulb earlier than striatum-derived cells. In the olfactory bulb, cortex-derived cells produce more cells and more dopaminergic neurons in the glomerular layer than striatum-derived cells. Cortex-derived cells also give rise to more astrocytes and less neurons in the striatum than striatum-derived cells. Thus, history matters; cortex-derived neural stem cells in the subependyma give rise to progeny in the olfactory bulb and striatum but in different proportions than striatum-derived neural stem cells.
神经干细胞可从小鼠胚胎皮质中分离出来，但在成年皮质中不能持续存在。相比之下，来自纹状体胚胎生发区的神经干细胞在成年室管膜下持续存在。Emx1谱系分析表明，皮质来源的神经干细胞存活并向腹侧迁移到室管膜下，在那里它们与宿主纹状体神经干细胞混合[S. Willaime-Morawek等人（2006年）《细胞生物学杂志》175卷，第159 - 168页]。皮质来源的细胞在室管膜下增殖更快，比纹状体来源的细胞更早到达嗅球。在嗅球中，皮质来源的细胞在肾小球层比纹状体来源的细胞产生更多的细胞和更多的多巴胺能神经元。皮质来源的细胞在纹状体中也比纹状体来源的细胞产生更多的星形胶质细胞和更少的神经元。因此，来源很重要；室管膜下皮质来源的神经干细胞在嗅球和纹状体中产生后代，但比例与纹状体来源的神经干细胞不同。
