Seissler Jochen
Diabetes Center, Medical Clinic Innenstadt, Ludwig-Maximilians-University Munich, Ziemssenstrasse 1, München 80336, Germany.
Curr Diab Rep. 2008 Apr;8(2):94-100. doi: 10.1007/s11892-008-0018-x.
About 10% of patients with the clinical presentation of type 2 diabetes suffer from an autoimmune form of diabetes associated with a rapid decline of residual beta-cell mass and subsequent development of insulin dependency. In this condition, called latent autoimmune diabetes in adults (LADA), there are clinical and metabolic features intermediate between type 1 and type 2 diabetes. Recent studies provide novel information on the immune markers associated with progressive beta-cell loss in LADA patients. However, LADA pathogenesis is still poorly understood; further studies are needed to establish general recommendation for preventing and treating this subtype of autoimmune diabetes.
约10%有2型糖尿病临床表现的患者患有自身免疫性糖尿病，其与残余β细胞量迅速下降及随后胰岛素依赖的发展有关。在这种称为成人隐匿性自身免疫性糖尿病（LADA）的病症中，存在1型和2型糖尿病之间的临床和代谢特征。最近的研究提供了与LADA患者β细胞进行性丧失相关的免疫标志物的新信息。然而，LADA的发病机制仍知之甚少；需要进一步研究以制定预防和治疗这种自身免疫性糖尿病亚型的一般建议。
