成骨细胞中的Notch信号通路。

Notch signaling in osteoblasts.

作者信息

Canalis Ernesto

机构信息

Department of Research, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, CT 06105, USA.

出版信息

Sci Signal. 2008 Apr 29;1(17):pe17. doi: 10.1126/stke.117pe17.

DOI:10.1126/stke.117pe17

PMID:18445833

Abstract

Bone remodeling is the result of the coordinated activity of osteoblasts, which form new matrix, and osteoclasts, which resorb bone. Notch proteins are single-pass transmembrane receptors that determine cell fate. Recent gain-of-function and loss-of-function experiments reveal a suppressive effect of Notch in osteoblast and osteoclast differentiation in development and in the postnatal bone, which establishes a role for Notch signaling in bone remodeling.

摘要

骨重塑是成骨细胞和破骨细胞协同活动的结果，成骨细胞形成新的基质，破骨细胞吸收骨质。Notch蛋白是决定细胞命运的单次跨膜受体。最近的功能获得和功能丧失实验揭示了Notch在发育过程和成体骨的成骨细胞及破骨细胞分化中具有抑制作用，这确立了Notch信号在骨重塑中的作用。