Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Curr Osteoporos Rep. 2013 Jun;11(2):126-9. doi: 10.1007/s11914-013-0145-4.
Notch signaling plays context-dependent roles in the development and maintenance of many cell types and tissues in mammals. In the skeleton, both osteoblasts and osteoclasts require Notch signaling for proper differentiation and function, and the specific roles of Notch are dependent on the differentiation status of the cell. The recent discovery of activating NOTCH2 mutations as the cause of Hajdu-Cheney syndrome has highlighted the significance of Notch signaling in human bone physiology.
Notch 信号在哺乳动物许多细胞类型和组织的发育和维持中发挥着依赖于背景的作用。在骨骼中，成骨细胞和破骨细胞都需要 Notch 信号来进行适当的分化和功能，而 Notch 的具体作用依赖于细胞的分化状态。最近发现激活的 NOTCH2 突变是 Hajdu-Cheney 综合征的原因，这凸显了 Notch 信号在人类骨骼生理学中的重要性。
