布鲁氏菌病患者间歇性使用利福平诱发急性间质性肾炎。

Acute interstitial nephritis induced by intermittent use of rifampicin in patient with brucellosis.

作者信息

Salih S Bin, Kharal M, Qahtani M, Dahneem L, Nohair S

机构信息

Division of Internal Medicine, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia.

出版信息

Saudi J Kidney Dis Transpl. 2008 May;19(3):450-2.

PMID:18445910

Abstract

Acute oliguric renal failure (ARF) developed in a patient 2 days after she was started on intermittent anti-Brucella therapy including rifampicin. The clinical picture was compatible with acute allergic interstitial nephritis. Renal histology revealed mainly acute tubular necrosis with mild tubulo-interstitial mononuclear cellular infiltrate. Intermittent therapy, as in our patient, has been the major factor in the development of rifampicin induced ARF in cases reviewed in literature.

摘要

一名患者在开始接受包括利福平在内的间歇性抗布鲁氏菌治疗两天后出现急性少尿性肾衰竭（ARF）。临床表现符合急性过敏性间质性肾炎。肾脏组织学检查主要显示急性肾小管坏死，并伴有轻度肾小管间质单核细胞浸润。如我们的患者那样的间歇性治疗，是文献中所报道的利福平诱发ARF病例发生的主要因素。