Ortiz A, Barat A, Oliva H
Unidad de Diálisis y Servicio de Anatomía Patológica, Fundación Jiménez Díaz, Madrid.
Nefrologia. 2001 Jan-Feb;21(1):92-4.
A case of acute renal failure requiring dialysis and associated with a characteristic, fulminant clinical course following the intermittent administration of rifampicin is presented. Renal biopsy showed severe tubular injury and a mild interstitial mononuclear cell infiltrate. Withdrawal of rifampicin led to a compete resolution of renal injury. We review the literature on the pathogenesis and treatment of this syndrome and we discuss the different substrates for acute renal failure induced by rifampicin.
本文报告一例急性肾衰竭病例，该病例需要透析治疗，且在间歇性服用利福平后出现典型的暴发性临床病程。肾活检显示严重的肾小管损伤和轻度的间质单核细胞浸润。停用利福平后，肾损伤完全缓解。我们回顾了关于该综合征发病机制和治疗的文献，并讨论了利福平所致急性肾衰竭的不同底物。
