Närvänen Tero, Seppälä Kari, Antikainen Osmo, Yliruusi Jouko
Orion Corporation, Orion Pharma, Orionintie 1, PO Box 65, 02101 Espoo, Finland.
AAPS PharmSciTech. 2008;9(1):282-7. doi: 10.1208/s12249-008-9043-y. Epub 2008 Feb 5.
The purpose of this research was to study the feasibility of the new image analysis method in the particle size determination of the granules. The method is capable of forming a three-dimensional topographic image of a sample surface from a digital picture. In the method, a flat granule bed surface was illuminated from three different directions, using the three primary colors (red, green, and blue). One color picture was taken by a digital camera, after which a topographic image of the object surface was constructed. The particle size distribution was then calculated from the image data. The particle size analysis method was tested both off-line and on-line. Off-line particle size measurement results determined by the image analysis method corresponded quite well to those of sieve analysis in the size fraction range 250-1,000 microm. In on-line application, images were successfully retrieved and median granule size trend could be calculated and followed during fluid bed granulations.
本研究的目的是探讨新图像分析方法在颗粒粒度测定中的可行性。该方法能够从数码照片形成样品表面的三维地形图。在该方法中，使用三原色（红、绿、蓝）从三个不同方向照射平坦的颗粒床表面。用数码相机拍摄一张彩色照片，然后构建物体表面的地形图。然后根据图像数据计算粒度分布。该粒度分析方法进行了离线和在线测试。通过图像分析方法测定的离线粒度测量结果与在250 - 1000微米粒度范围内的筛分分析结果相当吻合。在在线应用中，成功获取了图像，并且在流化床制粒过程中可以计算并跟踪颗粒中位径趋势。
