Puoci Francesco, Cirillo Giuseppe, Curcio Manuela, Iemma Francesca, Parisi Ortensia Ilaria, Castiglione Mariarosaria, Picci Nevio
Dipartimento di Scienze Farmaceutiche, Università della Calabria, Arcavacata di Rende, Italy.
Drug Deliv. 2008 May;15(4):253-8. doi: 10.1080/10717540802006724.
Biomedical applications of antioxidants have increased dramatically since the link between human diseases and oxidative stress was established. This paper focuses on alpha -tocopherol and on the possibility of employing molecularly imprinted polymers as a controlled release device for alpha-tocopherol in gastrointestinal simulating fluids. Polymers were synthesized using methacrylic acid as functional monomer and ethylene glycol dimethacrylate as cross-linker. Considerable differences in recognition characteristics between imprinted and non-imprinted polymers, both in organic and in aqueous media, were observed. Imprinted polymers bound much more alpha-tocopherol and showed a controlled/sustained drug release capacity in gastrointestinal simulating fluids.
自从人类疾病与氧化应激之间的联系被确立以来，抗氧化剂的生物医学应用急剧增加。本文重点关注α-生育酚，以及在胃肠道模拟液中使用分子印迹聚合物作为α-生育酚控释装置的可能性。以甲基丙烯酸为功能单体、乙二醇二甲基丙烯酸酯为交联剂合成了聚合物。在有机介质和水性介质中，均观察到印迹聚合物和非印迹聚合物在识别特性上存在显著差异。印迹聚合物结合了更多的α-生育酚，并在胃肠道模拟液中表现出控释/缓释药物的能力。
