Cho Joo-Jang, Hwang Woo-Jun, Hong Seung-Heon, Jeong Hyun-Ja, Lee Hye-Jung, Kim Hyung-Min, Um Jae-Young
Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk, Republic of Korea.
Int J Neurosci. 2008 May;118(5):635-45. doi: 10.1080/00207450701242628.
This study investigated the relationship between iridological constitution and angiotensinogen (AGN) gene polymorphism in hypertensives. In addition to angiotensin converting enzyme gene, AGN genotype is also one of the most well studied genetic markers of hypertension. Furthermore, iridology, one of complementary and alternative medicine, is the diagnosis of the medical conditions through noting irregularities of the pigmentation in the iris. Iridological constitution has a strong familial aggregation and is implicated in heredity. Therefore, the study classified 87 hypertensive patients with familial history of cerebral infarction and controls (n = 88) according to Iris constitution, and determined AGN genotype. As a result, the AGN/TT genotype was associated with hypertension (chi2 = 13.413, p < .05). The frequency of T allele was 0.92 in patients and 0.76 in controls (chi2 = 13.159, p < .05). In addition, iridological constitutional classification increased the relative risk for hypertension in the subjects with AGN/T allele. These results suggest that AGN polymorphism predicts hypertension, and iridological constitutional classification enhances the risk for hypertension associated with AGN/T in a Korean population.
本研究调查了高血压患者虹膜体质与血管紧张素原（AGN）基因多态性之间的关系。除血管紧张素转换酶基因外，AGN基因型也是研究最为深入的高血压遗传标记之一。此外，虹膜学作为补充替代医学的一种，是通过观察虹膜色素沉着异常来诊断疾病状况。虹膜体质具有很强的家族聚集性且与遗传有关。因此，该研究根据虹膜体质对87例有脑梗死家族史的高血压患者及对照组（n = 88）进行分类，并确定AGN基因型。结果显示，AGN/TT基因型与高血压相关（χ2 = 13.413，p < 0.05）。患者中T等位基因频率为0.92，对照组为0.76（χ2 = 13.159，p < 0.05）。此外，虹膜体质分类增加了携带AGN/T等位基因受试者患高血压的相对风险。这些结果表明，AGN多态性可预测高血压，且在韩国人群中，虹膜体质分类增加了与AGN/T相关的高血压风险。
