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对持续性或复发性特发性三叉神经痛患者进行后颅窝重复探查。

Repeat posterior fossa exploration for patients with persistent or recurrent idiopathic trigeminal neuralgia.

作者信息

Amador Nelly, Pollock Bruce E

机构信息

Department of Neurological Surgery, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

出版信息

J Neurosurg. 2008 May;108(5):916-20. doi: 10.3171/JNS/2008/108/5/0916.

Abstract

OBJECT

Patients with trigeminal neuralgia (TN) and persistent or recurrent facial pain after microvascular decompression (MVD) typically undergo less invasive procedures in the hope of providing pain relief. The outcomes and risks of repeat posterior fossa exploration (PFE) for these patients are not clearly understood.

METHODS

From September 2000 to November 2006, 29 patients (14 men, 15 women) underwent repeat PFE. The mean number of surgeries per patient at the time of repeat PFE was 3.2 (range 1-6). The mean follow-up duration after surgery was 33.7 months.

RESULTS

Compression of the trigeminal nerve was noted in 24 patients (83%) by an artery (13 patients, 45%), vein (4 patients, 14%), or Teflon (7 patients, 24%). Four patients (14%) who underwent operations elsewhere had incorrect cranial nerves decompressed at their first surgery. Only MVD was performed in 18 patients (62%) and a partial nerve section (PNS) was performed in 11 patients (38%). An excellent facial pain outcome (no pain, no medications required) was achieved and maintained for 80% and 75% of patients at 1 and 3 years after surgery, respectively. Patients with Burchiel Type 1 TN were pain free without medications (91% at 1 year and 85% at 3 years) more frequently than patients with Burchiel Type 2 TN (27% at both 1 and 3 years; hazard ratio = 5.4, 95% confidence interval 1.4-21.1, p = 0.02). Fifteen patients (52%) had new or increased facial numbness. Two patients (7%) developed anesthesia dolorosa; both had undergone PNS. Two patients (7%) had hearing loss after surgery.

CONCLUSIONS

Repeat PFE for patients with idiopathic TN has facial pain outcomes that are comparable with both percutaneous needle-based techniques and stereotactic radiosurgery. Patients with persistent or recurrent TN should be considered for repeat PFE, especially if other less invasive surgeries have not relieved their facial pain.

摘要

目的

患有三叉神经痛(TN)且在微血管减压术(MVD)后仍有持续性或复发性面部疼痛的患者通常会接受侵入性较小的手术,以期缓解疼痛。对于这些患者进行重复后颅窝探查术(PFE)的结果和风险尚不清楚。

方法

从2000年9月至2006年11月,29例患者(14例男性,15例女性)接受了重复PFE。在进行重复PFE时,每位患者的平均手术次数为3.2次(范围1 - 6次)。术后平均随访时间为33.7个月。

结果

24例患者(83%)的三叉神经被动脉(13例患者,45%)、静脉(4例患者,14%)或聚四氟乙烯(7例患者,24%)压迫。4例(14%)在其他地方接受手术的患者在首次手术时对错误的颅神经进行了减压。18例患者(62%)仅进行了MVD,11例患者(38%)进行了部分神经切断术(PNS)。术后1年和3年,分别有80%和75%的患者实现并维持了出色的面部疼痛结果(无疼痛,无需用药)。与Burchiel 2型TN患者相比,Burchiel 1型TN患者更频繁地无需用药即可无痛(1年时为91%,3年时为85%,而Burchiel 2型TN患者在1年和3年时均为27%;风险比 = 5.4,95%置信区间1.4 - 21.1,p = 0.02)。15例患者(52%)出现了新的或加重的面部麻木。2例患者(7%)发生了痛性麻木;二者均接受了PNS。2例患者(7%)术后出现听力丧失。

结论

对于特发性TN患者,重复PFE的面部疼痛治疗效果与经皮针刺技术和立体定向放射外科手术相当。对于持续性或复发性TN患者,应考虑进行重复PFE,尤其是在其他侵入性较小的手术未能缓解其面部疼痛的情况下。

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