Hashimoto Atsushi, Konno Ryuichi, Yano Hiroshi, Yoshikawa Masanobu, Tamaki Raita, Matsumoto Hideo, Kobayashi Hiroyuki
Department of Clinical Pharmacology, Tokai University School of Medicine, Isehara, Kanagawa 259-1143, Japan.
Eur J Pharmacol. 2008 May 31;586(1-3):221-5. doi: 10.1016/j.ejphar.2008.03.031. Epub 2008 Apr 1.
The behavioral effects induced by methamphetamine (5.0 mg/kg) were compared in the mutant mice lacking d-amino acid oxidase activity and normal mice. The mutant mice exhibited marked decline in the methamphetamine-induced stereotypy compared to the normal mice, whereas the mutant mice displayed a drastic augmentation in the locomotor activity evoked by methamphetamine compared to the normal mice. Because the d-serine levels in the brain of the mutant mice are significantly higher than those in the normal mice, the enhanced d-serine in the brain of the mutant mice could antagonize the methamphetamine-induced stereotypy via the N-methyl-d-aspartate receptors.
比较了缺乏d-氨基酸氧化酶活性的突变小鼠和正常小鼠中由甲基苯丙胺（5.0毫克/千克）诱导的行为效应。与正常小鼠相比，突变小鼠中甲基苯丙胺诱导的刻板行为明显减少，而与正常小鼠相比，突变小鼠中甲基苯丙胺诱发的运动活性急剧增强。由于突变小鼠大脑中的d-丝氨酸水平显著高于正常小鼠，突变小鼠大脑中增强的d-丝氨酸可能通过N-甲基-d-天冬氨酸受体拮抗甲基苯丙胺诱导的刻板行为。
