Weaver Kate, Kataoka Masako, Murray Jean, Muir Berenice, Anderson Elaine, Warren Ruth, Warsi Iqbal, Highnam Ralph, Glasier Anna
Reproductive Healthcare, Dean Terrace Family Planning Clinic, Edinburgh, UK.
Maturitas. 2008 Apr 20;59(4):315-22. doi: 10.1016/j.maturitas.2008.02.011. Epub 2008 Apr 29.
Hormone replacement therapy (HRT) is known to increase breast density, thus decreasing the sensitivity of cancer screening by mammography. Some authors recommend short cessation of HRT before mammography, but evidence showing the effect of such short cessation is limited. The purpose of this study is to examine whether a short cessation of HRT changes mammographic density.
Forty-eight women taking HRT agreed to have mammograms taken before and after stopping HRT for 4 weeks. Mammographic density was measured by Wolfe's four-point classification, six-categorical visual scale and two different computer methods (interactive-thresholding and SMF). Density values of mammography before and after the cessation of HRT were compared using Wilcoxon signed-rank test for categorical variables and paired t-test for continuous variables. Changes in breast pain and tenderness during mammography, radiation dose, compression force, and breast thickness were also recorded.
No significant changes in mammographic density were observed by either visual or computer methods. There were no significant changes in breast pain or in tenderness on mammograms before and after the month's cessation of HRT. Radiographic measurements were not significantly altered by the 4-week cessation of HRT.
In this screening population, a 4-week cessation of HRT before mammograms did not significantly alter mammographic density.
已知激素替代疗法（HRT）会增加乳房密度，从而降低乳腺钼靶检查癌症筛查的敏感性。一些作者建议在乳腺钼靶检查前短期停用HRT，但显示这种短期停用效果的证据有限。本研究的目的是检验短期停用HRT是否会改变乳腺钼靶密度。
48名接受HRT的女性同意在停用HRT 4周前后进行乳腺钼靶检查。采用沃尔夫四点分类法、六分类视觉量表和两种不同的计算机方法（交互式阈值法和SMF）测量乳腺钼靶密度。使用Wilcoxon符号秩检验对分类变量和配对t检验对连续变量比较HRT停用前后乳腺钼靶检查的密度值。还记录了乳腺钼靶检查期间乳房疼痛和压痛的变化、辐射剂量、压迫力和乳房厚度。
通过视觉或计算机方法均未观察到乳腺钼靶密度有显著变化。在停用HRT一个月前后，乳房疼痛或乳腺钼靶检查中的压痛均无显著变化。HRT停用4周后，影像学测量结果无显著改变。
在这个筛查人群中，乳腺钼靶检查前停用HRT 4周并未显著改变乳腺钼靶密度。
