Reynolds Sandra L, Haley William E, Kozlenko Nonna
University of South Florida, School of Aging Studies, Tampa, FL 33620, USA.
Am J Geriatr Psychiatry. 2008 May;16(5):425-32. doi: 10.1097/JGP.0b013e31816ff32e.
The authors prospectively examined whether depressive symptoms (DS) in older adults negatively affected active live expectancy (ALE), or remaining years free of disability, and mortality, independently and in the presence of chronic diseases, and after stratification by gender.
Prospective cohort study, first three waves (1993-1998) of the Asset and Health Dynamics Among the Oldest Old.
University of Michigan; analysis: University of South Florida.
Nationally representative sample of community-dwelling adults age 70 and older (N = 7,381).
DS (Center for Epidemiological Studies Depression, 8-item version), self-reported cancer, diabetes, heart disease, or stroke, difficulty with activities of daily living, death, and estimates of total, active, and disabled life expectancy.
DS reduced ALE by 6.5 years for young-old men (age 70), 3.2 years for old-old men (age 85), 4.2 years for young-old women, and 2.2 years for old-old women, and these effects remained significant at all ages and across gender even after controlling for chronic disease, the one exception being DS and cancer in old-old women. DS also reduced total life expectancy significantly, although controlling for some chronic diseases (particularly cancer and stroke) eliminated the effect of DS across age and gender groups.
Depressive symptoms represent a serious and distinct threat to independent functioning in older adults. Whether experienced alone, or in combination with chronic diseases, depressive symptoms shorten ALE substantially. Timely diagnosis and treatment of depressive symptoms in older adults may delay the onset of disability and improve the quality of life.
作者前瞻性地研究了老年人的抑郁症状(DS)是否会独立地以及在患有慢性疾病的情况下,对积极预期寿命(ALE)、无残疾剩余年限和死亡率产生负面影响,并按性别进行分层研究。
前瞻性队列研究,采用“最年长者资产与健康动态研究”的前三波数据(1993 - 1998年)。
密歇根大学;分析:南佛罗里达大学。
全国代表性的70岁及以上社区居住成年人样本(N = 7381)。
抑郁症状(流行病学研究中心抑郁量表,8项版本)、自我报告的癌症、糖尿病、心脏病或中风、日常生活活动困难、死亡以及总预期寿命、积极预期寿命和残疾预期寿命的估计值。
对于年轻老年男性(70岁),抑郁症状使积极预期寿命减少6.5年;对于老年男性(85岁),减少3.2年;对于年轻老年女性,减少4.2年;对于老年女性,减少2.2年。即使在控制了慢性疾病之后,这些影响在所有年龄段和不同性别中仍然显著,唯一的例外是老年女性的抑郁症状与癌症之间的关系。抑郁症状也显著降低了总预期寿命,尽管控制某些慢性疾病(特别是癌症和中风)后消除了抑郁症状在各年龄和性别组中的影响。
抑郁症状对老年人的独立功能构成严重且独特的威胁。无论单独出现还是与慢性疾病共同出现,抑郁症状都会大幅缩短积极预期寿命。及时诊断和治疗老年人的抑郁症状可能会延迟残疾的发生并提高生活质量。