Benoit G, Verdelli G, Hiesse C, Buffet C, Moukarzel M, Bensadoun H, Charpentier B, Jardin A, Fries D
Service d'Urologie, Centre hospitalier de Bicêtre-Université Paris-Sud, France.
Prog Urol. 1991 Aug-Sep;1(4):539-45.
Out of a series of 614 renal transplantation performed over a 4-year period, using cyclosporin and cimetidine, 100 patients developed a gastrointestinal complication: 9.6% of gastroduodenal ulcers, 4.4% of intestinal complications, 1.3% of pancreatic complications. 7 patients died: 5 from stress haemorrhages, 2 from peritonitis secondary to intestinal perforation. 32% of patients who developed an ulcer had a history of ulcer, but none of them developed a serious complication of their ulcer under cimetidine treatment. 18% of patients with colonic diverticula developed a diverticular complication after transplantation. The patients who died died from stress haemorrhage generally in a context of sepsis or from peritonitis secondary to intestinal perforation diagnosed after a delay of 24 hours.
在4年期间进行的614例肾移植系列手术中，使用环孢素和西咪替丁，100例患者出现了胃肠道并发症：9.6%为胃十二指肠溃疡，4.4%为肠道并发症，1.3%为胰腺并发症。7例患者死亡：5例死于应激性出血，2例死于肠穿孔继发的腹膜炎。发生溃疡的患者中有32%有溃疡病史，但在西咪替丁治疗下，他们均未出现溃疡的严重并发症。18%的结肠憩室患者在移植后出现憩室并发症。死亡患者通常死于败血症背景下的应激性出血或在延迟24小时后诊断出的肠穿孔继发的腹膜炎。
