Ventura-Juncá P, González A, Arrizaga N
Departamento de Pediatría, Unidad de Neonatología, Hospital Clínico Universidad Católica de Chile.
Rev Chil Pediatr. 1991 Sep-Oct;62(5):293-7.
The effectiveness of indomethacin versus usual medical treatment with fluid restriction to 75% of the volume given in the previous days, with or without frusemide (UMT), for the closure of hemodynamically significant patent ductus arteriosus (HSPDA) was retrospectively studied in 87 premature infants under 2,000 g admitted to our nursery from year 1978 throughout 1988. Among 16 babies, treated from the beginning with indomethacin and UMT, HSPDA was closed 72 h later in 14 (87.5%), versus only 14 closures in 71 babies (19.7%) treated by UMT alone (p < 0.01). Of the 57 babies whose HSPDA failed to close with UMT alone, 23 were given indomethacin and successful closure was seen in 16 (69.6%), while among 34 babies remaining on UMT alone, closure resulted in only 7 (20.6%) (p < 0.01). Intravenous route for administration and early use of indomethacin (before age 7 days) proved to have significantly higher success rates than oral route and use of the drug after age 7 days.
1978年至1988年期间，对我院收治的87例体重不足2000克的早产婴儿进行回顾性研究，比较消炎痛与常规药物治疗（将液体摄入量限制在前几日摄入量的75%，加或不加速尿，即UMT）对血流动力学显著的动脉导管未闭（HSPDA）的闭合效果。在16例一开始就接受消炎痛和UMT治疗的婴儿中，72小时后14例（87.5%）的HSPDA闭合，而仅接受UMT治疗的71例婴儿中只有14例闭合（19.7%）（p<0.01）。在57例仅用UMT治疗而HSPDA未闭合的婴儿中，23例给予消炎痛，16例（69.6%）成功闭合，而在仅继续接受UMT治疗的34例婴儿中，只有7例（20.6%）闭合（p<0.01）。静脉给药途径以及消炎痛的早期使用（7日龄前）的成功率明显高于口服途径以及7日龄后使用该药的成功率。
