非创伤性昏迷中的P300听觉事件相关电位。与格拉斯哥昏迷评分及苏醒的关联。
P300 auditory event-related potentials in nontraumatic coma. Association with Glasgow Coma Score and awakening.
作者信息
Gott P S, Rabinowicz A L, DeGiorgio C M
机构信息
EEG/Evoked Potential Laboratory, Los Angeles County, CA.
出版信息
Arch Neurol. 1991 Dec;48(12):1267-70. doi: 10.1001/archneur.1991.00530240071024.
Auditory event-related potentials (ERPs) were performed in 20 patients with nontraumatic coma to determine the presence of a P300 ERP in coma and its association with the Glasgow Coma Score and awakening (Glasgow Outcome Score, > or = 3). A standard "oddball" paradigm was used: frequent tone, 1 kHz; rare tone, 2 kHz and 4 Hz; probability, 20%. The Glasgow Coma Score was determined concurrently with the P300 ERP. Thirty percent (6/20) of the comatose patients had a P300 ERP. The mean Glasgow Coma Score was significantly higher for those with a P300 ERP. Eighty-three percent (5/6) of those with a P300 ERP awoke. Presence of a P300 ERP was associated significantly with awakening, but absence of a P300 ERP did not preclude it.
对20例非创伤性昏迷患者进行了听觉事件相关电位（ERP）检查，以确定昏迷患者中P300 ERP的存在及其与格拉斯哥昏迷评分和苏醒情况（格拉斯哥预后评分，≥3分）的相关性。采用标准的“oddball”范式：频繁出现的音调为1 kHz；罕见音调为2 kHz和4 Hz；概率为20%。在进行P300 ERP检查的同时确定格拉斯哥昏迷评分。30%（6/20）的昏迷患者有P300 ERP。有P300 ERP的患者平均格拉斯哥昏迷评分显著更高。有P300 ERP的患者中83%（5/6）苏醒。P300 ERP的存在与苏醒显著相关，但没有P300 ERP并不排除苏醒的可能。
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